Inhibitory effect of Biejiajianwan pills on tumor growth and proliferating cell nuclear antigen expression in mice bearing H22 cell-induced tumor / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the anti-tumor effect of Biejiajianwan pills and explore its mechanism.</p><p><b>METHODS</b>Mice bearing neoplasm induced by H22 cell inoculation were randomized into 4 groups, namely the negative control group, positive control group (with cyclophosphamide treatment), and high- and low-dose Biejiajianwan pill group. The tumor-bearing mice received corresponding treatments for 15 consecutive days, after which their thymuses and spleens were isolated and weighed to calculate the thymus and spleen indices. The tumor mass was also weighed and the tumor inhibition rate calculated. Immunohistochemistry was performed to evaluate the expression intensity of proliferating cell nuclear antigen (PCNA) in the tumor tissue.</p><p><b>RESULTS</b>The pills significantly inhibited the growth of the implanted tumor and reduced the expression of PCNA in the tumor.</p><p><b>CONCLUSION</b>One of the possible mechanisms of the anti-tumor effects of Biejiajian pills might be associated with the inhibition of PCNA expression in the tumor.</p>