Preparation of porous polylactic-acid/ bone matrix gelatin composite as scaffold materials for bone-tissue engineering / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To develop a novel porous poly lactic-acid(PLA)/bone matrix gelatin (BMG) bioactive composite biomaterial with supercritical carbon dioxide (SC-CO2) extraction and determine the optimal proportion of the ingredients by evaluating the physical and chemical characteristics and cellular compatibility of the composites.</p><p><b>METHODS</b>The PLA/BMG composite biomaterials with various PLA/BMG proportions were prepared with SC-CO2 technique and evaluated by macroscopic observation, porosity and mechanical assessment, and scanning electron micrograph (SEM). The optimal proportion of PLA/BMG was determined in conjunction with the results of cellular compatibility evaluation.</p><p><b>RESULTS</b>BMG proportion in BLA/BMG composite biomaterials prepared with SC-CO2 technique was positively associated with the cellular compatibility and porosity, and inversely with the mechanics of the prepared composite. The results showed BMG content of 30% in PLA/BMG composite was optimal.</p><p><b>CONCLUSION</b>The composite with PLA and BMG proportion of 73 possesses good physical and chemical characteristics and cellular compatibility, suggesting its potential as the bone implant biomaterial and bone-tissue engineering scaffold.</p>