Effects of soy isoflavone on levels of low-grade inflammatory peptides in rats with insulin resistance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1484-1486, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-232854
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of soy isoflavone (SIF) on low-grade inflammation in rats with high-fat diet-induced insulin resistance (IR) and explore the mechanisms of SIF in improving insulin sensitivity.</p><p><b>METHODS</b>The rats with high-fat diet-induced IR were randomly divided into one model control group and 3 SIF groups gavaged with SIF water solutions at the doses of 50, 150, and 450 mg/kg, respectively. One month after the treatment, fasting blood glucose (FBG), fasting insulin (FINS), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), resistin and adiponectin in the serum were detected by enzymatic method, radioimmunoassay, or enzyme-linked immunosorbent assay.</p><p><b>RESULTS</b>In the 150 and 450 mg/kg SIF groups, fasting body-weights, visceral adipose tissue deposition, FINS, resistin, TNF-alpha in serum, and IR index were lowered in comparison with the model control group, and in 450 mg/kg SIF group, serum IL-6 level was obviously lowered, and adiponectin increased. No differences were found in serum C-reactive protein levels between the 3 SIF groups.</p><p><b>CONCLUSION</b>Soy isoflavone may ameliorate insulin sensitivity by decreasing visceral adipose deposition and adjusting low-grade inflammatory molecules derived from white adipose tissue.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Glycine max
/
Sangre
/
Peso Corporal
/
Proteína C-Reactiva
/
Resistencia a la Insulina
/
Distribución Aleatoria
/
Química
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2006
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS