Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1268-1272, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-232999
ABSTRACT
Four crystalline forms of clopidogrel bisulfate were characterized by analytical techniques. Aiming to research the absorption characteristics of clopidogrel bisulfate polymorphs after taken orally by rat, and to estimate the influence of crystal form to pharmacodynamic action, four crystalline forms of clopidogrel bisulfate were administered intragastrically to rats, and high performance liquid chromatography (HPLC) was used to measure the contents of clopidogrel bisulfate and its metabolite in rat plasma. The metabolite of clopidogrel bisulfate was detected in rat plasma. There were significant deviations among four crystalline forms in the areas under curve of the metabolite of clopidogrel bisulfate. We concluded that the different crystal forms of clopidogrel bisulfate showed different pharmacokinetic characteristics, which might affect pharmacodynamic action.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Espectrofotometría Infrarroja
/
Difracción de Rayos X
/
Sangre
/
Ticlopidina
/
Rastreo Diferencial de Calorimetría
/
Farmacocinética
/
Inhibidores de Agregación Plaquetaria
/
Distribución Aleatoria
/
Química
/
Administración Oral
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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