Research progress of selective mGluR1 antagonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1167-1172, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-233017
ABSTRACT
As an important member of metabotropic glutamate receptors (mGluR), metabotropic glutamate receptor 1 (mGluR1) plays an important role in the signal transduction of central nervous system. Selective mGluR1 antagonists can block the signaling pathway activated by mGluR1 and exert a series of physiological actions including analgesia, antianxiety, antidepression, etc. Currently, the discovery and modification of selective mGluR1 antagonists have become a hot research focus. This paper reviews the structural catalogs of selective mGluR1 antagonists and their structure-activity relationships in the last decade.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Pirimidinas
/
Relación Estructura-Actividad
/
Tiazoles
/
Bencimidazoles
/
Dimensión del Dolor
/
Farmacocinética
/
Barrera Hematoencefálica
/
Transducción de Señal
/
Química
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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