Thermostability and crystal structure of anticancer drug dasatinib / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1104-1107, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-233027
ABSTRACT
This article studies the thermostability and the crystal structure of a new anticancer drug dasatinib. The thermostability of dasatinib was analyzed using the differential scanning calorimeter (DSC) and thermo gravimetric analyzer (TGA), and the structural characteristics of polymorphism and crystalline transformation was determined using the X-ray powder diffractometry (XRD) with in-situ high temperature accessories. The results showed that dasatinib has at least two different crystal forms. The form-I has one crystalline water and form-II one and half, and in a heating-up processing both of them would change their crystal structures. After losing their crystalline water, both would change into the same crystalline form with no crystalline water. Their melting points were almost the same form-I was 285.68 degrees C and form-II was 285.50 degrees C. The results of the study method would provide a comprehensive reference for the quality evaluation of dasatinib.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pirimidinas
/
Temperatura
/
Termogravimetría
/
Tiazoles
/
Difracción de Rayos X
/
Rastreo Diferencial de Calorimetría
/
Estructura Molecular
/
Química
/
Cristalización
/
Inhibidores de Proteínas Quinasas
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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