Synthesis and biological evaluation of sorafenib thiourea derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1093-1097, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-233030
ABSTRACT
Basing on the market multi-target antitumor agent sorafenib, a series of sixteen 4-[4-(2-methyl-aminoacyl-pyridyl)]oxylphenyl aryl thiourea derivatives were designed and synthesized. Their structures were identified by the spectra of 1H NMR, MS and elemental analysis. The evaluation of antitumor bioactivities in vitro was done by MTT method. It was shown that the synthesized compounds had antitumor activities and compounds 1a, 1d, 1i and 1j showed better or equal antitumor activity on sorafenib.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Compuestos de Fenilurea
/
Tiourea
/
Estructura Molecular
/
Química
/
Niacinamida
/
Línea Celular Tumoral
/
Proliferación Celular
/
Antineoplásicos
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS