The receptors and entry of measles virus: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-9, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-233275
ABSTRACT
Measles virus is an enveloped virus with a non-segmented negative-sense RNA genome. Two envelope glycoproteins on the viral surface, namely hemagglutinin (H) and membrane fusion protein (F), are responsible for the virus entry into susceptible host cells. The specific interaction between H and its cellular receptors is a key step in successful virus infection, determining the infectivity and tissue tropism of the measles virus. Thus far, three H receptors have been identified, including the complement regulatory molecule CD46, the signaling lymphocyte activation molecule (SLAM) and the cell adhesion molecule Nectin-4. Here, we reviewed our molecular understanding on the recognition mechanism of these receptors by the viral H protein, aiming to promote future studies on antiviral drug design and measles virus-based oncolytic therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Receptores Virales
/
Virulencia
/
Antígenos CD
/
Moléculas de Adhesión Celular
/
Receptores de Superficie Celular
/
Proteína Cofactora de Membrana
/
Proteínas de la Fusión de la Membrana
/
Miembro 1 de la Familia de Moléculas Señalizadoras de la Activación Linfocitaria
/
Hemaglutininas Virales
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2013
Tipo del documento:
Artículo
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