Your browser doesn't support javascript.
loading
Diffuse large B-cell lymphoma of testis: a clinicopathologic and immunophenotypic study of 58 cases / 中华病理学杂志
Chinese Journal of Pathology ; (12): 589-592, 2013.
Artículo en Chino | WPRIM | ID: wpr-233386
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathologic features, immunophenotype, diagnosis and differential diagnosis, and prognostic factors of testicular diffuse large B-cell lymphoma (DLBCL).</p><p><b>METHODS</b>The clinical and pathologic profiles of 58 cases of testicular DLBCL were investigated.Immunohistochemical stainings and EBER1/2 in situ hybridization were performed on formalin fixed tissues.</p><p><b>RESULTS</b>The average age of the patients was 62.1 years, and the median age was 65 years. The course of disease was short in most of the cases. Clinical stages at diagnosis were mainly stage I or II (87.9%, 51/58). Forty eight patients (82.8%) had unilateral testis involvement. Inguinal lymphadenopathy was observed in 12 (20.7%) patients and the other organs were seldom involved. Morphologically, centroblast-like neoplastic cells infiltrated interstitial tissue of testis diffusely and invaded into seminiferous tubules. Tunica albuginea and vessels were involved in 14 (24.1%) and 10 (17.2%) patients, respectively. Immunophenotype analysis showed predominant non-GCB type of DLBCL (48/58, 82.8%) by Hans classification. No EBV infection was detected. Follow-up data were available in 48 (82.8%) patients. Twenty eight patients (58.3%) died of the disease. One-year, 3-year, and 5-year overall survivals were 55.7%, 31.6% and 27.6%, respectively. Age (older than 60 years), B-symptoms, high serum level of LDH, advanced Ann Arbor stage as well as lack of combination of therapy were associated with a poor prognosis.</p><p><b>CONCLUSIONS</b>This large series of testicular DLBCL mainly present with local disease at diagnosis. Most cases show non-GCB immunophenotype. Despite early clinical stage at presentation, the prognosis is poor. Combined chemotherapy postoperation may prolong survival of the patients.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Cirugía General / Neoplasias Testiculares / Vincristina / Prednisona / Orquiectomía / Neprilisina / Protocolos de Quimioterapia Combinada Antineoplásica / Doxorrubicina / Tasa de Supervivencia Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Adulto / Anciano / Aged80 / Niño / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Pathology Año: 2013 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Cirugía General / Neoplasias Testiculares / Vincristina / Prednisona / Orquiectomía / Neprilisina / Protocolos de Quimioterapia Combinada Antineoplásica / Doxorrubicina / Tasa de Supervivencia Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Adulto / Anciano / Aged80 / Niño / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Pathology Año: 2013 Tipo del documento: Artículo