Ph+ acute lymphoblastic leukemia combined with lung and brain invasive aspergillosis / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 610-613, 2006.
Article
en Zh
| WPRIM
| ID: wpr-233535
Biblioteca responsable:
WPRO
ABSTRACT
This study was aimed to investigate the clinical features and therapy of Ph(+) acute lymphoblastic leukemia (Ph(+)ALL) combined with invasive aspergillosis. A series of examination, including routine blood and bone marrow picture analysis, chest roentgenography, cranial computerized tomography and detection of cell genetics etc were carried out for a Ph(+)ALL patient combined with invasive aspergillosis. This patient received chemotherapy with DVCP, idarubicin and imatinib mesylate and was treated with sporanox and amphotericin B (Amb; including Amb-L) and cerebrotomy for drainage because the invasive aspergillosis occurred during myelosuppression. The results showed that patient gained complete remission and the invasive aspergillosis was controlled successfully. It is concluded that patient with Ph(+)ALL has poor prognosis despite intensive conventional chemotherapy, imatinib mesylate may prove to be an effective treatment for Ph(+)ALL. Because detection rate of the fungus is very low, itraconazole in combination with surgical excision of focus is the best treatment of lung and brain invasive aspergillosis.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Piperazinas
/
Pirimidinas
/
Aspergilosis
/
Benzamidas
/
Encefalopatías
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Itraconazol
/
Usos Terapéuticos
/
Diagnóstico
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2006
Tipo del documento:
Article