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Study on the correlation among quantification of HBV-DNA and HBeAg, anti-HBe in hepatitis B carriers / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 709-711, 2006.
Artículo en Chino | WPRIM | ID: wpr-233889
ABSTRACT
<p><b>OBJECTIVE</b>To better understand the duplication of hepatitis B virus (HBV) in order to improve clinical diagnoses and treatments via quantitative measurement of HBV-DNA and comparison of correlation of HBV-DNA with HBeAg and anti-HBe.</p><p><b>METHODS</b>For 883 hepatitis B patients with positive HBsAg, HBV-DNA was measured by COBAS AMPLICOR HBV MONITOR reagent and COBAS AMPLICOR quantitative PCR instrument. Microparticle enzyme immunoassay analysis (MEIA) was then carried out with fully automatic enzyme immunoassay analysis instrument made by Abbott Axsym from the U.S. to measure HBeAg and anti-HBe. Correlation was analysed by SPSS.</p><p><b>RESULTS</b>(1)Positive correlation between 690 HBV-DNA positive and HBeAg positive with r= 0. 505 (P< 0.01) was found with mean values asHBV-DNA7.12 x 10(12) copies/ml;HBeAg218.31 S/CO. HBV-DNA10(4) copies/ml, HBeAg 104 S/CO; HBV-DNA 10(5)-10(8) copies/ml, HBeAg 112 S/CO; HBV-DNA 10(9)-10(15) copies/ml, HBeAg 252 S/CO. (2) No correlation was found between 193 HBV-DNA and anti-HBe + with r= -0.052(P= 0.477> 0.05) with Mean HBV-DNA 8.0x 10(10) copies/ml anti-HBe 0.18 S/CO.</p><p><b>CONCLUSION</b>HBV-DNA and HBeAg appeared to have had linear correlation, showing that HBeAg> 100 S/CO,HBV-DNA> 10(4) copies/ml and hepatitis B virus were reproduced. However, HBV-DNA did not show linear correlation with anti-HBe as HBeAg negative and anti-HBe positive, the level of hepatitis B viral replication decrease slightly. But the virus load is still high. Infectivity can not neglect.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Replicación Viral / ADN Viral / Portador Sano / Virus de la Hepatitis B / Reacción en Cadena de la Polimerasa / Técnicas para Inmunoenzimas / Carga Viral / Diagnóstico / Alergia e Inmunología / Genética Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Replicación Viral / ADN Viral / Portador Sano / Virus de la Hepatitis B / Reacción en Cadena de la Polimerasa / Técnicas para Inmunoenzimas / Carga Viral / Diagnóstico / Alergia e Inmunología / Genética Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2006 Tipo del documento: Artículo