Detection of CD95 and CD95L mRNA expression after liver transplantation using SYBR real-time PCR during acute rejection / 南方医科大学学报
Journal of Southern Medical University
; (12): 185-188, 2006.
Article
en Zh
| WPRIM
| ID: wpr-234165
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of CD95 and CD95L mRNAs after liver transplantation and investigate the role of CD95 and CD95L in acute liver allograft rejection.</p><p><b>METHODS</b>The expressions of CD95 and CD95L mRNAs of peripheral blood lymphocyte from 56 liver allograft recipients were examined using SYBR real-time PCR.</p><p><b>RESULTS</b>CD95 and CD95L mRNA levels in the recipients with acute rejection were significantly higher than those without rejection (P<0.01), and the elevation occurred about 2 days earlier than that of alanine aminotransferase and aspartate aminotransferase.</p><p><b>CONCLUSION</b>CD95 and CD95L are related to acute liver allograft rejection and their mRNA expression level may serve as an indicator for prediction and diagnosis of acute rejection episodes.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Compuestos Orgánicos
/
Cirugía General
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ARN Mensajero
/
Linfocitos
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Expresión Génica
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Reacción en Cadena de la Polimerasa
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Enfermedad Aguda
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Trasplante de Hígado
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Receptor fas
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Diagnóstico
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2006
Tipo del documento:
Article