PPARGC1A gene Thr394Thr G/A polymorphism and its association with type 2 diabetes mellitus and insulin resistance in a Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 550-553, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-234363
ABSTRACT
<p><b>OBJECTIVE</b>To examine the association of the Thr394Thr polymorphism of PPARGC1A gene with type 2 diabetes (T2DM), insulin resistance (IR) and other metabolic disorders in a Chinese population.</p><p><b>METHODS</b>Three hundred and seven subjects including 151 T2DM patients and 156 normal glucose tolerant controls (NC) were enrolled in this study. The Thr394Thr G/A polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Glucose, insulin, lipids levels were determined in all subjects. Body mass index (BMI), waist circumferences, index of homeostasis model assessment-insulin resistance (HOMA-IR) and blood pressure were also measured.</p><p><b>RESULTS</b>The diabetic subjects had higher levels of BMI, waist circumferences, blood systolic pressure, triglycerides and lower levels of high density lipoprotein-cholesterol (HDL-C) compared with those of control subjects (P<0.05). About 43.7% (66/151) of the T2DM subjects had the AG genotype, while 37.2% (58/156) in the NC group. The frequency of the A allele was 0.225 in T2DM, and 0.186 in the NC subjects. There were no significant differences either in genotype or allelic distribution of G/A polymorphism between the two groups. In the T2DM group, subjects with AA and GA genotypes had significantly higher levels of HOMA-IR, waist circumferences and lower levels of HDL-C (P<0.05) than those carrying GG genotype. HOMA-IR in subjects with AA and AG were significantly higher than those with GG genotype in both groups.</p><p><b>CONCLUSION</b>The A allele of the Thr394Thr (G-->A) polymorphism of the PPARGC1A gene was associated with insulin resistance, and may be related to central obesity and decreased HDL-C levels in Chinese population. The relationship between this polymorphism and T2DM needs further investigation.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Transcripción
/
Resistencia a la Insulina
/
Estudios de Casos y Controles
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Diabetes Mellitus Tipo 2
/
Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma
/
Genética
/
Proteínas de Choque Térmico
/
Metabolismo
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2010
Tipo del documento:
Artículo
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