To identify a novel HLA-DRB1 allele in Chinese by sequencing / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 333-334, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-234407
ABSTRACT
<p><b>OBJECTIVE</b>To identify a novel HLA-DRB1 allele in Chinese.</p><p><b>METHODS</b>A novel HLA-DR allele was detected by PCR-SSP and SBT in a patient with leukemia.</p><p><b>RESULTS</b>The sequence of the novel allele was different from all other known alleles. The novel allele differed from the closet matching allele HLA-DRB1*1404 by one nucleotide substitution in exon 2, at position 33 T>C, this resulted in an amino acid change from Tyr to His at codon 17.</p><p><b>CONCLUSION</b>The novel allele is confirmed as a new HLA allele and it was officially named HLA-DRB1*1461 by WHO Nomenclature Committee in May, 2006.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antígenos HLA-DR
/
Reacción en Cadena de la Polimerasa
/
Análisis de Secuencia de ADN
/
Pueblo Asiatico
/
Alelos
/
Cadenas HLA-DRB1
/
Genética
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2010
Tipo del documento:
Artículo
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