Research on progress and prospect of kinase S6K1 / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 935-949, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-234481
ABSTRACT
Obesity is a prevalent metabolic disorder, which seriously affects human health and has become the world's public health problem. Kinase S6K1, an important downstream effector of mammalian target of rapamycin (mTOR), influences specific pathological responses, including obesity, type 2 diabetes and cancer. Presently, S6K1 has become an attractive therapeutic target in the treatment of these disorders. Here, the functions of kinase S6K1, its molecular regulation mechanisms, related pathogenesis of disease and relevant small molecular inhibitors are reviewed. Finally, the prospect of research toward S6K1 is expected as well.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Proteínas Quinasas S6 Ribosómicas 70-kDa
/
Diabetes Mellitus Tipo 2
/
Serina-Treonina Quinasas TOR
/
Metabolismo
/
Neoplasias
/
Obesidad
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2014
Tipo del documento:
Artículo
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