Analysis of NF-κB and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma
Korean Journal of Urological Oncology
; : 63-68, 2016.
Article
en Ko
| WPRIM
| ID: wpr-23460
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma (RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival. MATERIALS AND METHODS: Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels. RESULTS: Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage (p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels (p=0.573). CONCLUSIONS: The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pronóstico
/
Recurrencia
/
Factores de Transcripción
/
Inmunohistoquímica
/
Carcinoma de Células Renales
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Urological Oncology
Año:
2016
Tipo del documento:
Article