The effect of 4-hexylresorcinol on xenograft degradation in a rat calvarial defect model / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 29-2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-23467
ABSTRACT
BACKGROUND:
The objective of this study was to evaluate xenograft degradation velocity when treated with 4-hexylresorcinol (4HR).METHODS:
The scapula of a cow was purchased from a local grocery, and discs (diameter 8 mm, thickness 1 mm) were prepared by trephine bur. Discs treated with 4HR were used as the experimental group. Untreated discs were used as the control. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), antibacterial test, endotoxin test, and scanning electron microscopy (SEM) were performed on the discs. In vivo degradation was evaluated by the rat calvarial defect model.RESULTS:
The XRD and FT-IR results demonstrated successful incorporation of 4HR into the bovine bone. The experimental disc showed antibacterial properties. The endotoxin test yielded results below the level of endotoxin contamination. In the SEM exam, the surface of the experimental group showed needle-shaped crystal and spreading of RAW264.7 cells. In the animal experiments, the amount of residual graft was significantly smaller in the experimental group compared to the control group (P = 0.003).CONCLUSIONS:
In this study, 4HR was successfully incorporated into bovine bone, and 4HR-incorporated bovine bone had antibacterial properties. In vivo experiments demonstrated that 4HR-incorporated bovine bone showed more rapid degradation than untreated bovine bone.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Escápula
/
Difracción de Rayos X
/
Microscopía Electrónica de Rastreo
/
Espectroscopía Infrarroja por Transformada de Fourier
/
Trasplantes
/
Experimentación Animal
/
Xenoinjertos
/
Hexilresorcinol
Límite:
Animales
Idioma:
Inglés
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Año:
2016
Tipo del documento:
Artículo
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