Study on mechanism of biminne in treating allergic rhinitis / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect and mechanism of Biminne, a Chinese herbal compound preparation, for treatment of allergic rhinitis (AR).</p><p><b>METHODS</b>AR model of mouse was induced by intraperitoneal injection of ovalbumin (OVA), and the changes in behavior, proliferative activity of splenic lymphocyte, serum levels of total IgE and OVA specific IgE were observed.</p><p><b>RESULTS</b>Biminne showed effects in reducing the frequency of sneezing and nasal rubbing, inhibiting the proliferation of splenic lymphocyte stimulated by phyto-hemagglutinin (PHA) and OVA, and lowering the levels of serum total IgE and OVA specific IgE.</p><p><b>CONCLUSION</b>Biminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.</p>