Study on correlationship of TCM syndrome type and expression of ICAM-1, CD62P in patients with ischemic stroke / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 225-227, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-234906
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlationship between TCM Syndrome type with changes of neutrophil surface intercellular adhesion molecule-1 (ICAM-1) and platelet membrane P selectin (CD62P) in patients with ischemic stroke for exploring the pathogenesis of the disease.</p><p><b>METHODS</b>Seventy-two patients with ischemic stroke were dividcd into 3 typing groups according to TCM syndrome-differentiation, the Meridian-phlegm stagnancy group (MPS), the visceral phlegm-heat accumulation group (VPHA) and the qi-deficiency with blood stasis group (QDBS), 24 in each group. Besides, a control group consisted of 24 healthy subjects was set up. Blood levels of ICAM-1 and CDP62 expression were monitored by flow cytometry.</p><p><b>RESULTS</b>Blood levels of ICAM-1 and CD62P expression in ischemic stroke patients were significantly higher than those in healthy subjects (P < 0.01). Among the three type groups, ICAM-1 expression was significantly higher in MPS than that in the VPHA and the QDBS group (P<0.01), and CD62P expression in the MPS and the QDBS group was significantly higher than that in the VPHA (P <0.01).</p><p><b>CONCLUSION</b>Blood levels of ICAM-1 and CD62P expression in different typing of patients with ischemic stroke are different. ICAM-1 expression reflects the pathological state of phlegm retention or phlegm-stasis mutual bindings, CD62P expression reflected the blood stasis state in organism, these evidences suggest that MPS may be the key pathogenic factor of ischemic stroke.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Molécula 1 de Adhesión Intercelular
/
Selectina-P
/
Accidente Cerebrovascular
/
Diagnóstico Diferencial
/
Medicina Tradicional China
Tipo de estudio:
Estudio diagnóstico
Límite:
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2005
Tipo del documento:
Artículo
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