iRhoms; Its Functions and Essential Roles
Biomolecules & Therapeutics
;
: 109-114, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-23492
ABSTRACT
In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and trafficking of tumor necrosis factor-alpha (TNF-α) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarified that the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer's disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptido Hidrolasas
/
Neoplasias de la Mama
/
Neoplasias Esofágicas
/
Regulación hacia Abajo
/
Queratodermia Palmar y Plantar Difusa
/
Membrana Celular
/
Factor de Necrosis Tumoral alfa
/
Drosophila
/
Retículo Endoplásmico
/
Serina Proteasas
Límite:
Humanos
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2016
Tipo del documento:
Artículo
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