Plasma cell leukemia in North India: retrospective analysis of a distinct clinicohematological entity from a tertiary care center and review of literature
Blood Research
;
: 23-30, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-23502
ABSTRACT
BACKGROUND:
Plasma cell leukemia (PCL) is a rare and aggressive plasma cell neoplasm. In PCL, clonal plasma cells comprise ≥20% of the peripheral blood (PB) leukocytes and/or the absolute clonal PB plasma cell count is ≥2×10(9)/L. Primary PCL (PPCL) originates de novo, whereas, secondary PCL (SPCL) evolves from pre-existing multiple myeloma.METHODS:
Clinicohematological features, immunophenotypic profile, and survival of PCL patients were analyzed retrospectively.RESULTS:
Between January 2007 and December 2014, ten PPCL and four SPCL patients were investigated (8 PPCLs and 3 SPCLs had complete clinical data). All were North Indians, sharing common geography and ethnicity. Our cohort showed less frequent renal failure, more frequent hepatomegaly, and non-secretory type disease. In contrast to western literature, flow cytometric immunophenotyping of our cohort revealed altered expression of CD138 (67%), CD56 (33%), and CD20 (0%). With novel therapeutic agents, these PPCL patients had a median overall survival of 15 months.CONCLUSION:
We highlight that our PPCL patients from North India had distinct clinicohematological and immunophenotypic profiles. The significance of our findings must be tested in a larger patient cohort and must be supported by molecular and cytogenetic investigations to unmask possible significant effects on pathogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Células Plasmáticas
/
Atención Terciaria de Salud
/
Leucemia de Células Plasmáticas
/
Estudios Retrospectivos
/
Estudios de Cohortes
/
Inmunofenotipificación
/
Citogenética
/
Insuficiencia Renal
/
Neoplasias de Células Plasmáticas
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Blood Research
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS