Expression of Caspase-8 and Bcl-2 in the cartilage loose bodies in patients with Kashin-Beck disease / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1314-1317, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-235135
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of Caspase-8 and Bcl-2 in the formation of loose bodies in Kashin-Beck disease (KBD).</p><p><b>METHODS</b>Specimens of cartilage loose bodies were collected from 50 adult patients with KBD, and the samples of articular cartilage were collected from 10 healthy adults to serve as control. Avidin-biotin alkaline phosphatase immunohistochemistry was employed to examine Bcl-2 and Caspase-8 positivities in the chondrocytes in the loose bodies.</p><p><b>RESULTS</b>In KBD loose bodies, the percentage of chondrocytes positive for Bcl-2 and Caspase-8 [(18.40∓8.78)% and (67.54∓12.29)%, respectively] were significantly higher than those of the control group [(12.25∓1.58)% and (24.70∓4.35)%, respectively]. Caspase-8 was found to promote chondrocyte apoptosis in the loose bodies, and this effect overrode the apoptosis-suppressing effect of Bcl-2. Bcl-2 and Caspase-8 positivities were found mainly in the deep hypertrophic chondrocytes in the cartilage or in cells adjacent to the bone tissues.</p><p><b>CONCLUSION</b>KBD loose bodies contain an increased percentage of apoptotic chondrocytes positive for Bcl-2 and Caspase-8. The apoptosis-inducing effect of Caspase-8 was a dominant feature in the cartilage pathology of KBD compared to the apoptosis-suppressing effect of Bcl-2.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Cartílago
/
Estudios de Casos y Controles
/
Apoptosis
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Caspasa 8
/
Enfermedad de Kashin-Beck
/
Cuerpos Libres Articulares
/
Metabolismo
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2011
Tipo del documento:
Artículo
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