Impact of gender on the dose-effect relationship of cisatracurium / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1287-1289, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-235142
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the impact of gender differences on the dose-effect relationship of cisatracurium.</p><p><b>METHODS</b>Eighty ASA class I or II patients (40 male and 40 female patients) undergoing elective abdominal surgeries received a single-dose intravenous injection of midazolam and fentanyl. The male and female patients were subdivided into 4 equal groups to receive a intravenous bolus of 20, 30, 40, or 50 µg/kg of cisatracurium. The neuromuscular block was measured using a neuromuscular transmission monitor, and the responses were defined in terms of the percentages of maximum suppression in T1 of TOF of the adductor pollicis muscle. According to log-probit transformation of the data of the dose and response, the dose-response curve of cisatracurium was established through linear regression. The onset time of vecuronium was also observed.</p><p><b>RESULTS</b>The ED95 value of cisatracurium in male patients was 67.4±4.4 µg/kg, significantly higher than that in female patients (48.7±1.0 µg/kg, P<0.05). No significant variation in the onset time was found in the 4 dose groups of either male or female patients (P>0.05).</p><p><b>CONCLUSION</b>Female patients are more sensitive to cisatracurium than male patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Cirugía General
/
Atracurio
/
Factores Sexuales
/
Procedimientos Quirúrgicos Electivos
/
Bloqueo Neuromuscular
/
Relación Dosis-Respuesta a Droga
/
Abdomen
/
Fenómenos Farmacológicos
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2011
Tipo del documento:
Artículo
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