Investigation of mRNA expression of collagen genes in oral squamous cell carcinoma and paired normal tissue / 南方医科大学学报
Journal of Southern Medical University
; (12): 1197-1199, 2011.
Article
en Zh
| WPRIM
| ID: wpr-235164
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mRNA expression of collagen genes in oral squamous cell carcinoma (OSCC) and paired normal oral mucosal tissue.</p><p><b>METHODS</b>The differential mRNA expressions of collagen genes between 30 OSCC tissues and the paired normal oral mucosal tissues were detected by RT-PCR.</p><p><b>RESULT</b>The relative expression level of COL1A1 mRNA in the 30 cancerous tissues was up-regulated by 2.78 folds as compared with its expression in the paired normal samples, suggesting its significant overexpression in OSCC (P<0.001). The expression levels of COL1A2, COL4A1, COL4A2, and COL5A2 mRNA in the cancerous tissues were up-regulated by 1.07, 1.15, 1.27, and 1.16 folds compared to those in paired normal samples (P>0.05).</p><p><b>CONCLUSION</b>COL1A1 mRNA overexpression may play an important role in the carcinogenesis of OSCC and can be a potential molecular marker of OSCC.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
ARN Mensajero
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Neoplasias de la Boca
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Carcinoma de Células Escamosas
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Colágeno
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Colágeno Tipo I
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Genética
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Metabolismo
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2011
Tipo del documento:
Article