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Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction / 南方医科大学学报
Journal of Southern Medical University ; (12): 1142-1145, 2011.
Artículo en Chino | WPRIM | ID: wpr-235177
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction (CI).</p><p><b>METHODS</b>In the venous blood samples from 250 patients with cerebral infarction and 250 control samples, the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR-sequencing. SHEsis software was used to analyze the association between the results of genotyping and the occurrence of CI.</p><p><b>RESULTS</b>The cerebral infarction group and the control groups showed significant differences in the allele and genotype frequencies of rs189897 and rs2212020 (P<0.05). The A-C haplotype was the protective factor against CI, and the subjects with the haplotype had a lowered risk for CI than those without this haplotype (0.131).</p><p><b>CONCLUSION</b>rs189897 and rs2212020 in ITGA9 gene are closely related to CI, and its A-C haplotype is the protective factor against CI.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Integrinas / Infarto Cerebral / Polimorfismo de Nucleótido Simple / Alelos / Genética / Genotipo Tipo de estudio: Estudio pronóstico Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Southern Medical University Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Integrinas / Infarto Cerebral / Polimorfismo de Nucleótido Simple / Alelos / Genética / Genotipo Tipo de estudio: Estudio pronóstico Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Southern Medical University Año: 2011 Tipo del documento: Artículo