Preparation of tanshinone microemulsion and its absorption in rat intestine in situ / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare tanshinone microemulsion (Tan-ME) and investigate its properities and the absorption character in rat intestine in situ.</p><p><b>METHOD</b>The microemulsions were prepared and characterized using Zetapals Zeta potential/particle size analysis and atomic force microscope. A HPLC method for determination of tanshinone IIA in the intestinal flux was established. RESUILT The Tan-ME was fine droplet with an average droplet size of (32.25 +/- 6.59) nm. The results of Tan-ME absorption in small intestinal indicated that Tan-ME could improve the absorption of tanshinone IIA in rat small intestine, but the absorption coefficient of Tan-ME, Ka was influenced by the ratio of water-phase in Tan-ME.</p><p><b>CONCLUSION</b>Tan-ME could improve the absorption of tanshinone IIA in rat small intestine. Thus bioavailability of tanshinone was improved.</p>