Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 953-956, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-235282
ABSTRACT
<p><b>OBJECTIVE</b>To study the inhibition effect of taspine on mouse S180 sarcoma and its mechanism.</p><p><b>METHOD</b>The mouse S180 sarcoma model was established and used to observe the antitumor activity of taspine. The microvessel density and protein expressing of the VEGF, bFGF, Bcl-2 and Bax in the tumor were measured by immunohistochemistry.</p><p><b>RESULT</b>Taspine showed antitumor activity on the mouse S180 sarcoma in a good dose-dependent manner. The inhibition rates on tumor of taspine at low, middle and high concentrations were 39.08% , 43.99% and 48.60%, respectively. The microvessel density and protein expressing of the VEGF, bFGF, Bcl-2 and Bax in the tumor were decreased compared with the negative control. The ratio of Bax to Bcl-2 was increased.</p><p><b>CONCLUSION</b>Taspine has antitumor effect on the S180 sarcoma, and the mechanism may be through the way of decreasing the expressing of the VEGF, bFGF, Bcl-2 and Bax and inducing the vascular endothelial cell apoptosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Plantas Medicinales
/
Sarcoma 180
/
Química
/
Factor 2 de Crecimiento de Fibroblastos
/
Raíces de Plantas
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Berberidaceae
/
Línea Celular Tumoral
/
Factor A de Crecimiento Endotelial Vascular
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Artículo
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