No relation between ACE-I/D polymorphism and high altitude pulmonary edema in the Han Chinese / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 508-517, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-235322
ABSTRACT
<p><b>OBJECTIVES</b>To explore whether the angiotensin I -converting enzyme (ACE) I/D (insertion/ deletion) polymorphism is associated with the susceptibility to high altitude pulmonary edema (HAPE) in the Han Chinese.</p><p><b>METHODS</b>One hundred and forty-seven HAPE-p (HAPE patients) and 193 HAPE-r (HAPE resistants) were enrolled from the Yushu earthquake reconstruction workers in Qinghai province where the altitude is over 3 500 m above sea level. Blood samples were collected from each of the HAPE-p and HAPE-r groups. Information about physiological phenotypes was obtained via fieldwork investigation. The ACE-I/D polymorphism in HAPE-p and HAPE-r was detected by polymerase chain reaction (PCR).</p><p><b>RESULTS</b>The SaO2 was significantly lower while HR was significantly higher in HAPE-p group than those in HAPE-r group. The genotype frequencies of ACE-I/D for II, ID, DD in HAPE-r and HAPE-p groups were 0.430, 0.446, 0.124 and 0.435, 0.469, 0.095, respectively, the allelic frequencies of I and D were 0.650, 0.350 and 0.670, 0.330, respectively. The OR of ID, DD and D alleles relative to II for HAPE was 0.961 (0.610-1.514), 1.322 (0.634-2.758) and 1.080 (0.783-1.489). There was no significant difference of the genotypic and the allelic frequencies in ACE-I/D polymorphism between HAPE-p and HAPE-r groups.</p><p><b>CONCLUSIONS</b>There is no relation between ACE-I/D polymorphism and HAPE in the Han Chinese.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Edema Pulmonar
/
Estudios de Casos y Controles
/
Peptidil-Dipeptidasa A
/
Pueblo Asiatico
/
Alelos
/
Altitud
/
Frecuencia de los Genes
/
Genética
/
Genotipo
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Applied Physiology
Año:
2013
Tipo del documento:
Artículo
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