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A 1H NMR based metabonomics approach to progression of coronary atherosclerosis in a hamster model / 药学学报
Acta Pharmaceutica Sinica ; (12): 495-502, 2013.
Artículo en Chino | WPRIM | ID: wpr-235638
ABSTRACT
To obtain a better understanding of the progression of atherosclerosis and identify potential biomarkers, proton nuclear magnetic resonance spectroscopy (1H NMR)-based metabonomics was used to study the metabolic changes in the plasma of hamster fed with a high-fat/cholesterol diet. Plasma samples were collected at different time points during the progression of atherosclerosis and individual proton NMR spectra were visually and statistically assessed using multivariate analyses. NMR results for all samples showed a time-dependent development from physiological to pathophysiological status during atherosclerosis. Analysis of the identified biomarkers of atherosclerosis suggests that lipid and amino acid metabolisms are significantly disturbed, together with inflammation, oxidative stress, following cholesterol overloading. The results enriched our understanding of the mechanism of atherosclerosis and demonstrated the effectiveness of the NMR-based metabonomics approach to study such a complex disease.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Enfermedad de la Arteria Coronaria / Espectroscopía de Resonancia Magnética / Biomarcadores / Distribución Aleatoria / Colesterol / Mesocricetus / Estrés Oxidativo / Progresión de la Enfermedad / Análisis de Componente Principal Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Enfermedad de la Arteria Coronaria / Espectroscopía de Resonancia Magnética / Biomarcadores / Distribución Aleatoria / Colesterol / Mesocricetus / Estrés Oxidativo / Progresión de la Enfermedad / Análisis de Componente Principal Límite: Animales Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2013 Tipo del documento: Artículo