Recent progress of the aptamer-based antiviral drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 447-456, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-235644
ABSTRACT
Aptamers are capable of binding a wide range of biomolecular targets with high affinity and specificity. It has been widely developed for diagnostic and therapeutic purposes. Because of unique three dimensional structures and cell-membrane penetration, aptamers inhibit virus infection not only through binding specific target, such as the viral envelope, genomic site, enzyme, or other viral components, but also can be connected to each other or with siRNA jointly achieve antiviral activity. Taking human immunodeficiency virus and hepatitis C virus as examples, this paper reviewed the effects and mechanisms of aptamers on disturbing viral infection and replication steps. It may provide an insight to the development of aptamer-based new antiviral drugs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Oligodesoxirribonucleótidos
/
Farmacología
/
Replicación Viral
/
Proteínas del Envoltorio Viral
/
VIH
/
Genoma Viral
/
Hepacivirus
/
ARN Interferente Pequeño
/
Usos Terapéuticos
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2013
Tipo del documento:
Artículo
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