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Research progress in aromatic prenyltransferases originated from microorganisms / 药学学报
Acta Pharmaceutica Sinica ; (12): 161-169, 2013.
Artículo en Chino | WPRIM | ID: wpr-235687
ABSTRACT
The prenylation of aromatic compounds plays an important role in the natural product research because it not only gives rise to an astounding diversity of primary and secondary metabolites in plants, fungi and bacteria but also enhances the bioactivities and bioavailabilities of these compounds. However, further investigation of prenylated aromatic compounds is frequently hindered due to their low content in nature and difficulties in chemical synthesis. Cloning aromatic prenyltransferase genes followed by heterologous expression would be attractive tools for the chemoenzymatic synthesis of bioactive molecules. This review summarizes the classifications, structural investigations, enzymatic catalysis and other progress in aromatic prenyltransferases originated from microorganisms.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Especificidad por Sustrato / Bacterias / Estructura Molecular / Química / Clasificación / Dimetilaliltranstransferasa / Biología Sintética / Hongos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Especificidad por Sustrato / Bacterias / Estructura Molecular / Química / Clasificación / Dimetilaliltranstransferasa / Biología Sintética / Hongos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2013 Tipo del documento: Artículo