Synthetic biology toward microbial secondary metabolites and pharmaceuticals / 药学学报
Acta Pharmaceutica Sinica
;
(12): 155-160, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-235688
ABSTRACT
Microbial secondary metabolites are one of the major sources of anti-bacterial, anti-fungal, antitumor, anti-virus and immunosuppressive agents for clinical use. Present challenges in microbial pharmaceutical development are the discovery of novel secondary metabolites with significant biological activities, improving the fermentation titers of industrial microbial strains, and production of natural product drugs by re-establishing their biosynthetic pathways in suitable microbial hosts. Synthetic biology, which is developed from systematic biology and metabolic engineering, provides a significant driving force for microbial pharmaceutical development. The review describes the major applications of synthetic biology in novel microbial secondary metabolite discovery, improved production of known secondary metabolites and the production of some natural drugs in genetically modified or reconstructed model microorganisms.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bacterias
/
Productos Biológicos
/
Técnicas de Transferencia de Gen
/
Descubrimiento de Drogas
/
Fermentación
/
Biología Sintética
/
Ingeniería Metabólica
/
Hongos
/
Metabolismo
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS