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Genome-wide association study of high altitude pulmonary edema / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 101-105, 2014.
Artículo en Chino | WPRIM | ID: wpr-236374
ABSTRACT
<p><b>OBJECTIVE</b>High altitue pulmonary edema (HAPE) impacts seriously people's health at high altitude. Screening of susceptibility genes for HAPE will be used for the evaluation and protection of susceptible people.</p><p><b>METHODS</b>We performed a genome-wide association study (GWAS) using Affymetrix SNP array 6.0 in 23 HAPE patients and 17 healthy controls. GO and Pathway analysis softwares were used to analyze and draw gene network.</p><p><b>RESULTS</b>Thirty-nine SNPs were found to be significantly different between case and control groups (P < 10(-4)). GO and Pathway analysis of 27 genes around the 39 SNPs indicated that these genes mainly participate in the regulating of cell proliferation, regulation of nitrogen compound metabolic process and G-protein coupled receptor protein signaling pathway and so on.</p><p><b>CONCLUSION</b>It suggests that these SNPs and genes found in this study may be associated with the susceptibility of HAPE.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estudios de Casos y Controles / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Pueblo Asiatico / Mal de Altura / Estudio de Asociación del Genoma Completo / Genética / Hipertensión Pulmonar Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Adulto / Humanos Idioma: Chino Revista: Chinese Journal of Applied Physiology Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estudios de Casos y Controles / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Pueblo Asiatico / Mal de Altura / Estudio de Asociación del Genoma Completo / Genética / Hipertensión Pulmonar Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Adulto / Humanos Idioma: Chino Revista: Chinese Journal of Applied Physiology Año: 2014 Tipo del documento: Artículo