Genome-wide association study of high altitude pulmonary edema / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 101-105, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-236374
ABSTRACT
<p><b>OBJECTIVE</b>High altitue pulmonary edema (HAPE) impacts seriously people's health at high altitude. Screening of susceptibility genes for HAPE will be used for the evaluation and protection of susceptible people.</p><p><b>METHODS</b>We performed a genome-wide association study (GWAS) using Affymetrix SNP array 6.0 in 23 HAPE patients and 17 healthy controls. GO and Pathway analysis softwares were used to analyze and draw gene network.</p><p><b>RESULTS</b>Thirty-nine SNPs were found to be significantly different between case and control groups (P < 10(-4)). GO and Pathway analysis of 27 genes around the 39 SNPs indicated that these genes mainly participate in the regulating of cell proliferation, regulation of nitrogen compound metabolic process and G-protein coupled receptor protein signaling pathway and so on.</p><p><b>CONCLUSION</b>It suggests that these SNPs and genes found in this study may be associated with the susceptibility of HAPE.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estudios de Casos y Controles
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Mal de Altura
/
Estudio de Asociación del Genoma Completo
/
Genética
/
Hipertensión Pulmonar
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2014
Tipo del documento:
Artículo
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