Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 491-494, 2009.
Article
en Zh
| WPRIM
| ID: wpr-236469
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the association between the number of peripheral blood stem cells (PBSC) and cardiac function index (NYHA grade, left ventricular ejection fraction, LVEF, N-terminal-proB-type Natriuretic Peptide, NT-pro BNP) in patients with ischemic heart failure (IHF).</p><p><b>METHODS</b>A total of 199 patients hospitalized in our department between August 2007 and April 2008 due to IHF were included in this study. NYHA grade, LVEF (measured by echocardiography), plasma NT-proBNP and number of PBSC were analyzed.</p><p><b>RESULTS</b>PBSC number was significantly decreased in proportion with increasing NYHA grade and PBSC number was significantly lower in patients with NYHA IV than that with class II and III (all P<0.01). LVEF was positively correlated with PBSC number (r = 0.35, P = 0.001), NT-proBNP was negatively correlated with PBSC number (r = - 0.39, P = 0.009). Multiple regression analysis showed that LVEF and NT-proBNP were major determinants of PBSC (Beta = 0.14, - 0.25, 95% CI = -0.01 - 0.02, -0.18 - -0.04, P<0.05, P<0.01).</p><p><b>CONCLUSION</b>PBSC number was significantly correlated to cardiac function in IHF patients.</p>
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Índice:
WPRIM
Asunto principal:
Fragmentos de Péptidos
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Pronóstico
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Sangre
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Células Madre Hematopoyéticas
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Recuento de Células
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Análisis de Regresión
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Isquemia Miocárdica
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Disfunción Ventricular Izquierda
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Biología Celular
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Insuficiencia Cardíaca
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Año:
2009
Tipo del documento:
Article