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Changes of heart-type fatty acid-binding protein in children with chronic heart failure and its significance / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 99-101, 2013.
Artículo en Chino | WPRIM | ID: wpr-236862
ABSTRACT
<p><b>OBJECTIVE</b>To study serum levels of heart-type fatty acid-binding protein (h-FABP) in children with chronic heart failure (CHF), and the correlation between heart function and the level of h-FABP, with the aim of studying the significance of h-FABP in CHF.</p><p><b>METHODS</b>Thirty-six children with CHF, including 16 cases of endocardial fibroelastosis (EFE) and 20 cases of dilated cardiomyopathy (DCM) were enrolled in the study. Thirty healthy children sevred as the control group. Serum levels of h-FABP were determined using ELISA, and left ventricular ejection fraction (LVEF), cardiac index (CI) and fractional shortening of the left ventricle (LVSF) were measured by two-dimensional echocardiography in the CHF group.</p><p><b>RESULTS</b>Mean levels of h-FABP in the CHF group were significantly higher than in the control group (21.7±4.3 ng/mL vs 6.2±1.7 ng/mL; P<0.01). The worse the heart function, the higher the h-FABP levels (P<0.01). Mean levels of h-FABP in both the EFE and DCM groups were significantly higher than in the control group (P<0.01). Serum h-FABP concentrations were negatively correlated with LVEF, CI and LVSF (r=-0.65, -0.64 and -0.71 respectively; P<0.01) in the CHF group.</p><p><b>CONCLUSIONS</b>Serum h-FABP levels increase in children with CHF and are closely related to the severity of the condition. Serum h-FABP levels can be used as a biomarker for the diagnosis of heart failure and the evaluation of its severity.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Índice de Severidad de la Enfermedad / Cardiomiopatía Dilatada / Enfermedad Crónica / Fibroelastosis Endocárdica / Proteínas de Unión a Ácidos Grasos / Proteína 3 de Unión a Ácidos Grasos / Insuficiencia Cardíaca Límite: Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Índice de Severidad de la Enfermedad / Cardiomiopatía Dilatada / Enfermedad Crónica / Fibroelastosis Endocárdica / Proteínas de Unión a Ácidos Grasos / Proteína 3 de Unión a Ácidos Grasos / Insuficiencia Cardíaca Límite: Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2013 Tipo del documento: Artículo