Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 429-432, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-236924
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the interrelationship of genetic polymorphisms in folate metabolic enzymes (MTHFRC677T, MTHFRA1298C, MTRA2756G and MTRRA66G) and their combinative effects with colorectal cancer (CRC).</p><p><b>METHODS</b>A nested case-control study was designed and carried out. 140 CRC patients and 343 control subjects were included in this study. Polymorphisms of folate metabolic enzyme genes were genotyped by PCR-restriction fragment length polymorphism method. Risk of CRC was estimated by unconditional logistic model, and P value for interaction was calculated by likelihood test.</p><p><b>RESULTS</b>The allele of MTR2756G showed a positive association with CRC (OR = 2.04, 95% CI = 1.22 - 3.40). Those with MTHFR1298AA and MTR 2756AG/GG genotypes had an elevated risk with CRC (OR = 2.57, 95% CI, 1.42 -4.65), and their combinative effect showed a significant association with CRC (P = 0.04).</p><p><b>CONCLUSION</b>MTR2756G allele may be a risk factor of CRC, and interaction may exsit between polymorphisms of MTHFRA1298C and MTRA2756G. Further studies with larger sample and in different ethnic groups are needed.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Neoplasias Colorrectales
/
Estudios de Casos y Controles
/
Oportunidad Relativa
/
Reacción en Cadena de la Polimerasa
/
Predisposición Genética a la Enfermedad
/
Metilenotetrahidrofolato Reductasa (NADPH2)
/
Alelos
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2006
Tipo del documento:
Artículo
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