Identification of origins of marker chromosomes using fluorescence in situ hybridization / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 415-419, 2013.
Article
en Zh
| WPRIM
| ID: wpr-237236
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the value of fluorescence in situ hybridization (FISH) and bacterial artificial chromosome FISH (BAC-FISH) for the diagnosis for patients with marker chromosomes.</p><p><b>METHODS</b>Sixteen patients with marker chromosomes were analyzed with technologies including GTG-banding, Q-banding, multiplex FISH and BAC-FISH.</p><p><b>RESULTS</b>The marker chromosomes in the 16 patients were verified as der(Y) (2 cases), psu dic(Y) (1 case), psu dic(15) (1 case), dic(15) (1 case), del(Y) (1 case), r(X) (5 cases), i(14 or 22) (2 cases), i(18) (1 case).</p><p><b>CONCLUSION</b>FISH and BAC-FISH can both verify the origin of marker chromosomes and provide accurate information for the diagnosis and treatment of patients.</p>
Texto completo:
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Índice:
WPRIM
Asunto principal:
Marcadores Genéticos
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Aberraciones Cromosómicas
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Hibridación Fluorescente in Situ
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Diagnóstico
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Genética
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Enfermedades Genéticas Congénitas
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Métodos
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2013
Tipo del documento:
Article