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Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
Journal of Korean Medical Science ; : 1062-1067, 2015.
Artículo en Inglés | WPRIM | ID: wpr-23733
ABSTRACT
The records of 63 high-risk neuroblastoma patients with bone marrow (BM) tumors at diagnosis were retrospectively reviewed. All patients received nine cycles of induction chemotherapy followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT). Follow-up BM examination was performed every three cycles during induction chemotherapy and every three months for one year after the second HDCT/auto-SCT. BM tumor cells persisted in 48.4%, 37.7%, 23.3%, and 20.4% of patients after three, six, and nine cycles of induction chemotherapy and three months after the second HDCT/auto-SCT, respectively. There was no difference in progression-free survival (PFS) rate between patients with persistent BM tumor and those without during the induction treatment. However, after tandem HDCT/auto-SCT, the PFS rate was worse in patients with persistent BM tumor than in those without (probability of 5-yr PFS 14.7% +/- 13.4% vs. 64.2% +/- 8.3%, P = 0.009). Persistent BM tumor during induction treatment is not associated with a worse prognosis when intensive tandem HDCT/auto-SCT is given as consolidation treatment. However, persistent BM tumor after tandem HDCT/auto-SCT is associated with a worse prognosis. Therefore, further treatment might be needed in patients with persistent BM tumor after tandem HDCT/auto-SCT.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Protocolos de Quimioterapia Combinada Antineoplásica / Estudios Retrospectivos / Factores de Riesgo / Resultado del Tratamiento / Terapia Combinada / Neoplasias de la Médula Ósea / Trasplante de Células Madre / Quimioterapia de Inducción / Neoplasias Primarias Múltiples Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino / Recién Nacido Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Protocolos de Quimioterapia Combinada Antineoplásica / Estudios Retrospectivos / Factores de Riesgo / Resultado del Tratamiento / Terapia Combinada / Neoplasias de la Médula Ósea / Trasplante de Células Madre / Quimioterapia de Inducción / Neoplasias Primarias Múltiples Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino / Recién Nacido Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2015 Tipo del documento: Artículo