The contribution for the diagnosis of the tumor-like polypoid lesions of the gallbladder by SELDI-TOF-MS / 中华外科杂志
Chinese Journal of Surgery
;
(12): 525-527, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-237771
ABSTRACT
<p><b>OBJECTIVE</b>To detect the serum specific proteins in tumor-like polypoid lesions of the gallbladder patients and establish diagnostic model.</p><p><b>METHODS</b>Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic patterns of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data.</p><p><b>RESULTS</b>Preliminary screening out 22 representative specific proteins for the diagnosis of the tumor-like PLG. Analysis system under the conditions set selected 3 specific proteins to establish diagnostic model for the tumor-like PLG. The sensitivity and specificity of the model for the diagnosis of the tumor-like PLG were 100% and 89.4%, respectively.</p><p><b>CONCLUSION</b>SELDI-TOF-MS technique can select specific protein of the tumor-like PLG, and establish diagnostic model of the tumor-like PLG.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pólipos
/
Sangre
/
Proteínas Sanguíneas
/
Biomarcadores de Tumor
/
Sensibilidad y Especificidad
/
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
/
Diagnóstico
/
Neoplasias de la Vesícula Biliar
Tipo de estudio:
Estudio diagnóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2008
Tipo del documento:
Artículo
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