Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population / 中华男科学杂志
National Journal of Andrology
;
(12): 413-416, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-238010
ABSTRACT
<p><b>OBJECTIVES</b>To investigate Bsm I single nucleotide polymorphism (SNP) of vitamin D receptor gene (VDRG) in low-risk Chinese Han population and its relationship to the susceptibility to prostate cancer (PCa), and to discuss the possible reason for the racial difference of PCa.</p><p><b>METHODS</b>One hundred and three patients with PCa and 106 normal controls, mainly from Northern Chinese Han population, were enrolled in this study. Their blood samples were obtained, all of which were genotyped for Bsm I SNP by denaturing high performance liquid chromatography(DHPLC) methods using case-control study.</p><p><b>RESULTS</b>The distribution of genotype and allele had no significant difference between PCa patients and normal controls (P > 0.05). The frequencies for the bb, Bb and BB genotypes in PCa patients and normal controls were 92.23%/94.34%, 7.77%/5.66%, and 0/0, respectively. The frequencies for B and b allele were 3.88%, 96.12% and 2.91%, 97.09%, respectively.</p><p><b>CONCLUSIONS</b>The results indicate no significant relationship between the VDRG polymorphisms and PCa in Northern Chinese Han population. The distribution of VDRG Bsm I SNP varies in different ethnic populations, which may be one reason for the racial difference of PCa.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias de la Próstata
/
Estudios de Casos y Controles
/
China
/
Cromatografía Líquida de Alta Presión
/
Receptores de Calcitriol
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Etnología
/
Genética
/
Genotipo
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Anciano
/
Aged80
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2003
Tipo del documento:
Artículo
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