Synthesis of peptide fragment of melittin and the function of rheumatoid arthritis cure / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1031-1035, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-238285
ABSTRACT
To retain the anti-rheumatoid arthritis activity of melittin and to reduce the hemolysis and hypersusceptibility caused by melittin, a deletion peptide of melittin was synthesized. Its ant-inflammation effect was observed . A hydrophile peptide fragment of melittin was synthesized by standard solid-phase method. The product was analyzed by HPLC and MS. The relevant hemolysis and hypersusceptibility were tested. The rabbits' model of immune arthritis were established and treated. The results showed that the hemolysis rate for peptide fragment was less than 5%, the hypersusceptibility rate was less than 8%. The hydrophile peptide fragment of melittin may retain anti-rheumatoid arthritis activity and reduce the melittin-induced hemolysis and hypersusceptibility.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fragmentos de Péptidos
/
Artritis Reumatoide
/
Terapéutica
/
Usos Terapéuticos
/
Meliteno
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2005
Tipo del documento:
Artículo
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