Impedance effects of interleukin-6 on cyclophosphamide-induced hematopoietic damnification in dogs / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 798-801, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-238338
ABSTRACT
The aim of this study is to evaluate the effect of Interleukin-6 on cyclophosphamide-induced hematopoietic damnification. The doses of Interleukin-6 in 3 different regimens were hypodermally injected into dogs for 7 days respectively to establish the cyclophosphamide-induced hematopoietic damnification model. The effect of Interleukin-6 on the production of platelets and the amount of other cells in the dogs' bone marrow were determined on the 21st day. The results showed that Interleukin-6 significantly alleviated the reduction of platelet count and recovered the platelets level faster. The impedance effects of Interleukin-6 directed against hematopoietic damnification of bone marrow and spleen were shown by pathological examination. These suggest that the Interleukin-6 can significantly impede cyclophosphamide-induced hematopoietic damnification.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Trombocitopenia
/
Células de la Médula Ósea
/
Interleucina-6
/
Ciclofosfamida
/
Usos Terapéuticos
/
Leucopenia
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS