Effects of triptolide on anti-angiogenesis by reducing expression of urokinase plasminogen activator / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 778-781, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-238343
ABSTRACT
In order to unveil the anti-angiogenic mechanism of triptolide, we investigated the effects of triptolide on the proliferation, migration, angiogenesis and u-PA expression of cultured HUVECs. MTT assay found that triptolide could inhibit the proliferation of HUVECs, and three-dimensional culture system revealed that triptolide could curb the migration of HUVECs. The chick embryo chorioallantoic membrane (CAM) test showed that triptolide could inhibit angiogenesis. Real time quantitive RT-PCR showed the expression of u-PA of HUVECs was down-regulated by triptolide. Therefore, triptolide may inhibit the proliferation and migration of endothelial cell by way of reducing the expression of u-PA. These findings may conduce to the elucidation of the anti-angiogenic mechanism of triptolide.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fenantrenos
/
Venas Umbilicales
/
ARN Mensajero
/
Activador de Plasminógeno de Tipo Uroquinasa
/
Regulación hacia Abajo
/
Células Cultivadas
/
Inhibidores de la Angiogénesis
/
Biología Celular
/
Células Endoteliales
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2005
Tipo del documento:
Artículo
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