Studies on paclitaxel-loaded methoxy poly (ethylene glycol)/poly (L-lactic acid) diblock copolymer nanoparticles / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 715-718, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-238357
ABSTRACT
Paclitaxel-loaded methoxy poly (ethylene glycol )-b-poly (L-lactic acid) diblock copolymer nanoparticles (PMT) were prepared by a self-emulsification/solvent evaporation method. The PMT morphology, size and its distribution, and drug release in vitro were investigated by DLS, UV, TEM and HPLC. The results indicate that PMT show a spherical morphology with inner core and outer shell. The diameter (nm) of PMT increases with the increase of the drug-loaded amount. The initial burst release is not observed, the drug releasing rate in vitro is lower, and the accumulated release increases with the increase of replacement amout of the pH7. 4 medium. This study develops a new formulation for paclitaxel and provides an experimental basis for the intravenous administration of paclitaxel.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Poliésteres
/
Polietilenglicoles
/
Polímeros
/
Portadores de Fármacos
/
Química
/
Paclitaxel
/
Preparaciones de Acción Retardada
/
Nanopartículas
/
Inyecciones Intravenosas
/
Antineoplásicos Fitogénicos
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS