The role of cyclooxygenase on angiogenesis and endothelial progenitor cell mobilization in rat ischemic myocardium / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 833-836, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-238506
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of COX1 and COX2 on angiogenesis and endothelial progenitor cell mobilization in rats with experimental myocardial infarction (MI).</p><p><b>METHODS</b>The rats were randomly divided into 3 groups MI group, MI plus rofecoxib group and MI plus valeryl salicylate group. At the 7th day after operation, circulating EPCs, plasma VEGF and HIF-1alpha mRNA of ischemic myocardium were measured. At the 28th day post operation, capillary densities were also measured in ischemic myocardium.</p><p><b>RESULT</b>Compared with the MI group and the MI plus valeryl salicylate group, circulating EPCs, plasma VEGF, HIF-1alpha mRNA and capillary densities of ischemic myocardium were all decreased in MI plus rofecoxib group.</p><p><b>CONCLUSION</b>The present study revealed that COX2 play an important role with angiogenesis and endothelial progenitor cell mobilization in rat with experimental MI by modulating expression of VEGF and HIF-1alpha.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Células Madre
/
Sangre
/
Distribución Aleatoria
/
Inhibidores de la Ciclooxigenasa
/
Ratas Sprague-Dawley
/
Neovascularización Fisiológica
/
Biología Celular
/
Células Endoteliales
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2006
Tipo del documento:
Artículo
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