Your browser doesn't support javascript.
loading
Big data: the progress and applications of antibody repertoire sequencing / 南方医科大学学报
Journal of Southern Medical University ; (12): 463-467, 2015.
Artículo en Chino | WPRIM | ID: wpr-239155
ABSTRACT
Antibody, the major effector in adaptive immunity, plays key roles in protective and pathogenic immune responses. Integrative analyses of antibody development, differentiation, and maturation promote the research in immune mechanism, vaccine design, and therapies for autoimmune disorders. The development of next generation sequencing technologies has enabled large-scale characterization of functional antibody repertoires. With the advantages of next generation sequencing, antibody and antibody repertoire analysis have been successfully used in identification of HIV-1-broadly neutralizing antibodies, design of rationale structure-based vaccine, and development of immunology. With increasing sequence length and precision, improvement of experimental protocols and bioinformatics analyses, and development of single cell sequencing technology, antibody repertoire sequencing will expedite the research in antibody-related immune response, and thus facilitates vaccine design for infectious diseases, clinical diagnosis and interference of autoimmune diseases. This review introduces the technologies, progresses, applications, and caveats of antibody repertoire sequencing.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Vacunas / Química / VIH-1 / Anticuerpos Neutralizantes / Secuenciación de Nucleótidos de Alto Rendimiento / Anticuerpos / Formación de Anticuerpos Tipo de estudio: Guía de Práctica Clínica Límite: Humanos Idioma: Chino Revista: Journal of Southern Medical University Año: 2015 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Vacunas / Química / VIH-1 / Anticuerpos Neutralizantes / Secuenciación de Nucleótidos de Alto Rendimiento / Anticuerpos / Formación de Anticuerpos Tipo de estudio: Guía de Práctica Clínica Límite: Humanos Idioma: Chino Revista: Journal of Southern Medical University Año: 2015 Tipo del documento: Artículo