Identification of 3 novel HLA-A alleles A*24:224, A*24:225 and A*24:257 by sequence-based typing / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 415-417, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-239456
ABSTRACT
<p><b>OBJECTIVE</b>To verify 3 novel HLA-A alleles A*24224, A*24225 and A*24257 identified in Chinese Han individuals.</p><p><b>METHODS</b>No full matched results were obtained at HLA-A locus in HLA typing for China Marrow Donor Program (CMDP) using bi-allelic Sequence-Based Typing (SBT). The novel HLA alleles were identified with allele-specific amplification SBT.</p><p><b>RESULTS</b>All of the three probands had a novel nucleotide sequence at HLA-A locus. All of the 3 new sequences are most close to HLA-A*24020101 except for 1 or 2 nucleotide substitution in exon 2, which resulted in different changes in corresponding codons and encoded amino acids.</p><p><b>CONCLUSION</b>Three novel HLA-A alleles were confirmed and officially named as HLA-A*24224, HLA-A*24225 and HLA-A*24257 under the GenBank accession numbers JQ899198, JQ924283 and HG003642 by the WHO Nomenclature Committee for Factors of the HLA System in November 2012 and November 2013, respectively.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Prueba de Histocompatibilidad
/
Datos de Secuencia Molecular
/
Secuencia de Bases
/
China
/
Análisis de Secuencia de ADN
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Alelos
/
Etnología
/
Antígeno HLA-A24
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2015
Tipo del documento:
Artículo
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