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Association of T190C polymorphism of β3 adrenergic receptor gene with response to carvedilol in patients with chronic heart failure / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 101-104, 2015.
Artículo en Chino | WPRIM | ID: wpr-239525
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of T190C polymorphism of β3 adrenergic receptor gene (β3-AR) with chronic heart failure (CHF), and to evaluate the effect of this polymorphism on clinical response to β-AR blockade among patients with CHF.</p><p><b>METHODS</b>Three hundred and thirty patients with stable CHF receiving basic therapy for heart failure were included. Before initiation and 5 months after the maximal tolerated dose of carvedilol was reached, all indices including heart rate (HR), blood pressure (BP), left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), brain natriuretic peptide (BNP) level, 6 min walk distance were measured and compared with the indices of those with a T190C genotype. Distribution of the T190C polymorphisms in the control group and CHF group was compared.</p><p><b>RESULTS</b>The frequencies of T190C genotypes of the β3-AR gene have fit with the Hardy-Weinberg equilibrium. No significant difference was found between the frequencies of T190C alleles and genotypes between the two groups (P > 0.05). Compared with CC-homozygotes, TT-homozygous patients showed substantially greater improvement in LVEF and BNP (all P < 0.01).</p><p><b>CONCLUSION</b>No difference has been detected in the prevalence of the three genotypes between healthy and CHF subjects. The T190C variation of the β3-AR gene was not associated with increased risk for CHF. CHF patients with a T allele have greater response to carvedilol than those carrying a C allele in ethnic Han Chinese.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Propanolaminas / Carbazoles / Enfermedad Crónica / Función Ventricular Izquierda / Receptores Adrenérgicos beta 3 / Usos Terapéuticos / Quimioterapia / Genética / Insuficiencia Cardíaca Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Propanolaminas / Carbazoles / Enfermedad Crónica / Función Ventricular Izquierda / Receptores Adrenérgicos beta 3 / Usos Terapéuticos / Quimioterapia / Genética / Insuficiencia Cardíaca Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2015 Tipo del documento: Artículo