Aberrant DNA methylation and its targeted therapy in acute myeloid leukemia / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 387-394, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-239574
ABSTRACT
The occurrence and development of acute myeloid leukemia (AML) is not only related to gene mutations, but also influenced by abnormal epigenetic regulation, in which DNA methylation is one of the most important mechanisms. Abnormal DNA methylation may lead to the activation of oncogene and the inactivation of tumor suppressor gene, resulting in the occurrence of leukemia. The mutations of DNA methylation enzymes associated with AML may have certain characteristics. The AML with recurrent cytogenetic abnormalities is also related to abnormal methylation. Some fusion genes can alter DNA methylation status to participate in the pathogenesis of leukemia. In addition, chemotherapy drug resistance in patients with AML is associated with the change of gene methylation status. Considering the reversibility of the epigenetic modification, targeted methylation therapy has become a hotspot of AML research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Metilasas de Modificación del ADN
/
Leucemia Mieloide Aguda
/
Resistencia a Antineoplásicos
/
Metilación de ADN
/
Epigénesis Genética
/
Genética
/
Mutación
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2016
Tipo del documento:
Artículo
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