Study on the anticancer activities of the Clematis manshrica saponins in vivo / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the anticancer activity of the Clematis manshrica saponins in vivo.</p><p><b>METHOD</b>Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.</p><p><b>RESULT</b>The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively.</p><p><b>CONCLUSION</b>The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.</p>